Empower Pharmacy Tirzepatide

Overview

Tirzepatide is a dual GIP and GLP-1 receptor agonist used for the treatment of type 2 diabetes mellitus. It is administered as a once-weekly subcutaneous injection.

This compounded version is by Empower Pharmacy and the full details provided by the company can be found at here. Empower has been registered as Human Drug Compounding Outsourcing Facilities Under Section 503B of the Federal Food, Drug, and Cosmetic Act (FD&C Act) since 2016 and, at the time of this writing, was last inspected without concern on 8/28/2024.

The FDA website can be found here.

Mechanism of Action

Tirzepatide functions as both a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist. This dual action helps in:

• Improving glycemic control
• Reducing body weight

Niacinamide

Niacinamide, also known as nicotinamide, is a form of vitamin B3. In the context of tirzepatide injections, it serves several important functions:

• Stabilizer: It helps maintain the stability of the tirzepatide molecule in the solution.
• Absorption enhancer: Niacinamide may improve the absorption of tirzepatide when injected subcutaneously.
• Potential metabolic benefits: As a vitamin B3 derivative, niacinamide itself has some metabolic effects that may complement tirzepatide's action.

The addition of niacinamide to tirzepatide injections is part of the compounding process and may contribute to the overall efficacy and stability of the medication.

Clinical Efficacy

Clinical studies have shown that tirzepatide:

• Significantly reduces hemoglobin A1C levels compared to placebo
• Promotes weight loss in a dose-dependent manner
• May have potential benefits for non-alcoholic fatty liver disease (NAFLD) patients

Dosage and Administration

Tirzepatide is typically administered as follows:

• Once-weekly subcutaneous injection
• Available in various strengths (e.g., 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg)
• Dose is usually titrated over time to reach the target dose

Side Effects

Common side effects may include:

• Nausea
• Diarrhea
• Decreased appetite
• Vomiting
• Constipation
• Abdominal pain

Precautions

Tirzepatide should be used with caution in patients with:

• History of pancreatitis
• Severe gastrointestinal disease
• Diabetic retinopathy

Storage and Handling

Tirzepatide should be stored properly:

• Refrigerate at 2°C to 8°C (36°F to 46°F)
• Do not freeze
• Protect from light
• Can be stored at room temperature for up to 21 days

Compounding Information

Tirzepatide niacinamide injection is available as a compounded medication. It's important to note that compounded medications are not FDA-approved and should be used under the guidance of a healthcare professional.

<aside> Always consult with a healthcare provider before starting or changing any medication regimen. The information provided here is for educational purposes only and does not replace professional medical advice.