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PRFM (Platelet Rich Fibrin Matrix)

What is PRFM?

Platelet-Rich Fibrin Matrix (PRFM) is an advanced version of platelet-rich plasma (PRP) that is used in regenerative medicine. PRFM involves concentrating platelets and fibrin from a patient’s own blood to create a natural scaffold or cellular matrix that promotes healing and tissue regeneration. The process of creating PRFM includes:

           1.         Blood Collection: A small amount of the patient’s blood is drawn.

           2.         Centrifugation: The blood is processed in a centrifuge to separate its components.

           3.         Fibrin Matrix Formation: Calcium chloride is added to the platelet-rich plasma to form a fibrin matrix, which stabilizes and extends the release of growth factors over time.

How PRFM Differs from PRP

           1.         Composition:

           •           PRP: Contains a high concentration of platelets suspended in plasma.

           •           PRFM: Contains platelets within a fibrin matrix, which acts as a scaffold to support cell migration and the sustained release of growth factors.

           2.         Stability:

           •           PRP: Platelets in PRP are free-floating, leading to a faster but shorter duration of growth factor release lasting hours to days.

           •           PRFM: The fibrin matrix stabilizes platelets, allowing for a more controlled and extended release of growth factors which continue to work for days to weeks.

           3.         Preparation:

           •           PRP: Generally involves a single centrifugation step.

           •           PRFM: Includes an additional step where calcium chloride is added to convert PRP into a fibrin matrix.

Uses of PRFM

PRFM is utilized in various medical and aesthetic applications due to its enhanced regenerative properties. Some common uses include:

           1.         Orthopedics: To aid in the healing of tendons, ligaments, and joints, and to treat conditions such as osteoarthritis.

           2.         Aesthetics: For facial rejuvenation, hair restoration, under eye tear troughs, lips and improving skin texture and elasticity.

           3.         Wound Healing: To accelerate the healing of chronic wounds, surgical sites, and injuries.

           4.         Dentistry: To promote bone and tissue regeneration in procedures like dental implants and periodontal surgery.

           5.         PRFM is an ideal option for patients who have an autoimmune disease preventing them from being able to undergo conventional filler treatments.  

Number of treatments/frequency of treatments required to achieve desired results

Hair Growth: Three treatments every 4-6 weeks coupled with oral and or topical supplements/serums to achieve maximal results. Maintenance is one treatment yearly.

Under eyes, lips, and fine lines: two to three treatments 4-6 weeks apart

Complications of PRFM

While PRFM is generally considered safe, potential complications can include:

           1.         Infection: As with any procedure involving injections, there is a risk of infection at the injection site.

           2.         Pain and Swelling: Temporary pain, swelling, and bruising at the site of application are common.

           3.         Allergic Reactions: Although rare, some patients may experience allergic reactions to the materials used in the preparation process.

           4.         Blood Clotting Issues: Improper preparation or injection techniques may lead to abnormal blood clotting.

           5.         Variable Outcomes: The effectiveness of PRFM can vary based on individual patient factors, including the quality of the patient’s platelets and overall health condition.

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